谷氨酰胺

建议

2 项研究 · 1 条建议

最后更新: 2026年2月25日

谷氨酰胺 – 口腔黏膜炎
建议2 项研究

在癌症治疗期间,补充谷氨酰胺可能有助于减轻口腔黏膜炎的严重程度。

两项系统性综述表明,谷氨酰胺可以作为一种细胞保护剂,用于预防癌症患者的口腔黏膜炎。一项科克伦综述分析了多项随机对照试验,结果显示,在七种干预措施中,静脉注射谷氨酰胺对预防口腔黏膜炎具有一定效果,尤其是在骨髓移植环境中,但其证据强度不如冷疗或角质形成细胞生长因子。另一项系统性综述筛选了 268 篇文章(其中 96 篇符合纳入标准),这些文章来自 PubMed-Medline、科克伦图书馆和 Scopus,结果表明,口服谷氨酰胺在多项研究中均能持续降低化疗引起的口腔黏膜炎的发生率和严重程度。虽然谷氨酰胺的效果不如帕利弗明、冷疗和低功率激光疗法等方法显著,但两项综述都记录到,使用谷氨酰胺可以明显减少口腔黏膜炎的发生率和严重程度,这支持了其作为一种辅助预防策略的作用,并值得进一步进行验证性试验。

证据

作者: Bagán Sebastián, José Vicente, Chaveli López, Begonya

发布日期: 2016年1月1日

在一项对来自PubMed-Medline、Cochrane Library和Scopus数据库的268篇已识别文章(其中96篇符合纳入标准)进行的系统性综述中,口服谷氨酰胺被归类为具有细胞保护作用的药物之一——与舒曲率和透明质酸一起——这些药物均显示出能减少化疗引起的口腔黏膜炎的发病率和严重程度。虽然谷氨酰胺未能达到已证实有效治疗方法的前列(如帕利弗明、冷疗法、低功率激光),但细胞保护剂组在多项综述研究中都表现出一致的积极效果。作者建议进一步研究以确认这些益处。

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发布日期: 2010年1月1日

Cochrane系统评价发现,静脉注射谷氨酰胺是七种干预措施中疗效证据较弱的,这些干预措施可用于预防接受包括骨髓移植在内的癌症患者发生口腔黏膜炎。该评价评估了多项随机对照试验,这些试验评估了不同的预防策略。虽然谷氨酰胺显示出积极的结果,但其证据不如冷冻疗法或角质细胞生长因子那样充分,而且其益处可能仅限于纳入研究中评估的特定疾病和治疗情况。