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Diterbitkan: 1 Januari 2010
Satu kajian sistematik Cochrane yang menilai intervensi untuk mencegah mukositis oral dalam pesakit kanser mendapati bahawa krioterapi (cip ais) menunjukkan manfaat dalam mencegah mukositis. Kajian tersebut menilai pelbagai percubaan terkawal rawak merentasi pesakit dengan pelbagai jenis kanser yang menjalani pelbagai rawatan kanser termasuk pemindahan sumsum tulang. Krioterapi adalah salah satu daripada hanya dua intervensi (bersama-sama faktor pertumbuhan keratinosit) yang menunjukkan bukti manfaat terkuat di antara semua strategi yang dinilai untuk pencegahan mukositis.
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