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Diterbitkan: 1 Januari 2010
Sebuah tinjauan sistematis Cochrane yang mengevaluasi intervensi untuk mencegah mukositis oral pada pasien kanker menemukan bahwa krioterapi (serpihan es) menunjukkan manfaat dalam mencegah mukositis. Tinjauan tersebut menilai beberapa uji coba terkontrol secara acak pada pasien dengan berbagai jenis kanker yang menjalani berbagai perawatan kanker termasuk transplantasi sumsum tulang. Krioterapi adalah salah satu dari hanya dua intervensi (bersama dengan faktor pertumbuhan keratinosit) yang menunjukkan bukti manfaat terkuat di antara semua strategi yang dievaluasi untuk pencegahan mukositis.
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