Authors: Brayne, Carol, Cappuccio, Francesco, Khaw, Kay-Tee, Leng, Yue, Luben, Robert N., Surtees, Paul G., Wainwright, Nick W. J.
Published: March 17, 2015
A prospective cohort of 9,692 stroke-free participants aged 42-81 from the EPIC-Norfolk cohort followed for 9.5 years recorded 346 stroke cases. Long sleep was significantly associated with increased stroke risk (HR = 1.46, 95% CI 1.08-1.98) after full covariate adjustment. Short sleep showed a non-significant elevated risk (HR = 1.18, 95% CI 0.91-1.53). Persistently long sleepers and those with substantial increases in sleep duration over time had higher stroke risk compared to persistently average sleepers. An updated meta-analysis confirmed pooled HRs of 1.15 (95% CI 1.07-1.24) for short sleep and 1.45 (95% CI 1.30-1.62) for long sleep duration.
