Probiotics (Bifidobacterium)

Suggested

2 studies · 1 recommendation

Last updated: February 4, 2026

Probiotics (Bifidobacterium) – Hyperuricemia

Suggested2 studies

Bifidobacterium probiotics may help lower uric acid through gut-mediated metabolic pathways

Two studies comprising Mendelian randomization data from over 300,000 participants and a systematic literature review support probiotic intervention for hyperuricemia management. The meta-analysis using genetic instruments from MiBioGen (N=18,340) and CKDGen (N=288,649) cohorts established causal relationships between Bifidobacteriales/Bifidobacteriaceae and improved urate metabolism, with protective effects mediated through the DHA pathway at the MCM6/LCT locus. The systematic review confirmed that intestinal microbiota regulate urate transporter protein expression in enterocytes, providing an alternative excretion pathway when kidney function is compromised. Gut bacteria participate directly in purine metabolism and uric acid degradation, offering mechanistic rationale for probiotic supplementation to reduce serum urate levels and prevent associated complications like urolithiasis.

Evidence

Molecular mechanisms regulating uric acid metabolism in the human intestine, systematic literature review

Authors: G. S. Konyshko, N. A. Konyshko

Published: October 1, 2023

This systematic review of literature from 2000-2022 across Scopus, PubMed, eLIBRARY, and Google Scholar databases identified intestinal microbiota as having therapeutic potential for hyperuricemia and gout prevention. The review established that gut microflora metabolites regulate expression of urate transporter proteins in enterocytes, affecting both urate reabsorption and excretion pathways. The intestinal route serves as an alternative excretion pathway when renal excretion is impaired, with microbiota involvement in purine metabolism and uric acid degradation providing mechanistic support for probiotic interventions to prevent renal damage and urolithiasis associated with elevated uric acid.

View Source →

Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization

Authors: Guang Ning, Guang Ning, Hong Lin, Hong Lin, Huajie Dai, Huajie Dai, Jie Zheng, Jie Zheng, Jieli Lu, Jieli Lu, Mian Li, Mian Li, Min Xu, Min Xu, Qi Wang, Qi Wang, Shuangyuan Wang, Shuangyuan Wang, Tiange Wang, Tiange Wang, Tianzhichao Hou, Tianzhichao Hou, Weiqing Wang, Weiqing Wang, Xiaoyun Zhang, Xiaoyun Zhang, Yanan Hou, Yanan Hou, Yanyun Gu, Yanyun Gu, Yu Xu, Yu Xu, Yufang Bi, Yufang Bi, Yuhong Chen, Yuhong Chen, Zhiyun Zhao, Zhiyun Zhao

Published: March 1, 2023

Bidirectional Mendelian randomization using summary statistics from 211 microbiota taxa (MiBioGen N=18,340) and urate levels (CKDGen N=288,649) established causal relationships between specific gut bacteria and urate metabolism. Genetic correlation analysis supported significant MR results. The Victivallaceae family showed replicable causal effects on both gout and urate. The study identified that changes in gut microbiota can ameliorate host urate metabolism, with Bifidobacteriales and Bifidobacteriaceae specifically showing protective effects mediated through the DHA pathway at the MCM6/LCT genetic locus.

View Source →