2 studies · 1 recommendation
Last updated: February 25, 2026
Across 2 studies involving over 4,700 participants, hydrogenated fat consumption showed a consistent association with worse breast cancer outcomes. A case-control study of 520 women in Kerman found significantly higher hydrogenated fat intake among breast cancer patients compared to matched controls (p < 0.05). More critically, a prospective cohort study tracking 4,441 women with invasive breast cancer over 7 years demonstrated that those in the highest quintile of trans fat intake faced a 78% increased risk of all-cause mortality (HR = 1.78, 95% CI 1.35–2.32, P trend = 0.01), after adjusting for age, cancer stage, BMI, physical activity, and treatment. Minimizing hydrogenated fats and trans fats in the diet may reduce mortality risk for breast cancer patients.
Authors: Amiri-Moghaddam, Marjan, Ghadimi, Bahram, PourRanjbar, Muhammad
Published: January 1, 2016
A case-control study comparing 260 breast cancer patients with 260 matched controls in Kerman found a statistically significant difference in hydrogenated fat consumption between the two groups (p < 0.05, chi-square test). Women with breast cancer consumed more hydrogenated fats than controls, supporting the recommendation to limit intake of hydrogenated oils and trans fats.
Authors: Beasley, Jeannette M, Bersch, Andrew J, Egan, Kathleen M, Hampton, John M, Holick, Crystal N, Holmes, Michelle D, Newcomb, Polly A, Passarelli, Michael N, Titus-Ernstoff, Linda, Trentham-Dietz, Amy, Willett, Walter C
Published: July 1, 2011
In a prospective cohort of 4,441 women with invasive breast cancer and no prior recurrence, post-diagnosis dietary intake was assessed using a validated 126-item food frequency questionnaire. During 7 years of follow-up, women in the highest quintile of trans fat intake had a 78% higher risk of dying from any cause compared to the lowest quintile (HR = 1.78, 95% CI = 1.35-2.32, P trend = 0.01), after adjustment for age, cancer stage, menopausal status, smoking, BMI, physical activity, energy intake, and breast cancer treatment. Associations with breast cancer-specific mortality followed a similar pattern but did not achieve statistical significance.
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